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Lets break each down

then, the speed was increased by increments of 5 m/min, with 2 minutes of rest in between each increment, until the mice reached a speed where they were unable to run for the full 5-minute trial, defined by the mouse taking 25 total foot shocks or remaining on the shock grid for more than 5 consecutive seconds

Key Takeaway: Every-other-week dosing is primarily a topic for the maintenance phase and should only be initiated under strict medical guidance to prevent the return of old eating patterns

This approach allows the body to adjust and can help mitigate potential rebound weight gain while transitioning to a medication-free lifestyle